Vertex GPS: Guidance & Patient Support

Since 2012, more than 20,000 people have enrolled in Vertex GPS.* Once you've prescribed a
Vertex product to your patient, they may be eligible for our comprehensive program.

With the Vertex GPS Portal, you can:

  • Enroll eligible patients in Vertex GPS
  • Assist with coverage and reimbursement support
  • Keep track of treatment status, refill history, and compliance rate

Watch the video to learn more!

*Represents individuals both currently and previously enrolled in GPS, regardless of if they are now actively on a Vertex medication.

*Represents individuals both currently and previously enrolled in GPS, regardless of if they are now actively on a Vertex medication.

Enroll Patients in Vertex GPS in Just a Few Clicks

  1. Log on to the portal.
  2. Complete the form with your patient.
  3. Submit the form electronically.

To help you make the most of the portal, we've created instructional videos with tips for using certain features. If you have questions about getting set up, call 1-800-290-0011. 1-800-290-0011.

Watch the videos

Other Ways to Enroll Patients

Download the enrollment form

The enrollment form is an easy way to help your patients become part of Vertex GPS. Simply follow the steps below.

  1. Download the form.
    English Spanish
  2. Fill it out electronically and print, or print the blank form and fill it out
    by hand.
  3. Complete and sign all sections and pages with the patient or caregiver.
  4. Fax the completed form to 1-888-952-5933.


  1. Log on to
  2. Enter the Vertex product name in the medication field.
  3. Use the search term "GPS" or "enrollment."
  4. Complete the form with your patient.
  5. Submit electronically.


After patient enrollment, you can notify the patient or caregiver that a Patient Support Specialist will be reaching out soon.

About Vertex GPS

Image of HCP Brochure guide

Learn more about how Vertex GPS can provide product support to patients and caregivers.

Download the guide

Download the guide

How Vertex GPS Works With Centers

Patient Support Specialists can work with you and your staff by:

  • Assisting in patient enrollment for Vertex GPS
  • Verifying insurance requirements and coordinating product delivery through an in-network specialty pharmacy
  • Tracking and monitoring refills to help with Vertex treatment adherence
  • Notifying you of changes in your patient’s insurance coverage or new requirements
  • Communicating prior authorization renewal information
  • Summarizing patient information in an Enrolled Patient Report

Getting Your Patients Started With Vertex GPS

Personalized support from Vertex GPS begins at enrollment. After you have submitted the enrollment form, patients can expect to receive a welcome call from their dedicated Patient Support Specialist.

4 out of 5

patients on Vertex medicines in the
US are enrolled in Vertex GPS

As of 9/1/2020, based on in-network specialty pharmacy and Vertex GPS data.

Your patient’s specialist is here to help by:

1. Verifying insurance coverage and requirements

Vertex GPS can help determine coverage and any prior authorization requirements:

  • Patient Support Specialists will share the outcome and can help explore financial assistance options
  • For patients who have commercial insurance, Vertex may be able to help reduce their co-pay to as little as $0 per refill

Limitations apply. Annual assistance is limited to a maximum of $20,000. Not available to individuals with government-funded insurance such as Medicaid, Medicare, and TRICARE®. Vertex reserves the right to rescind, revoke or amend this assistance program at any time.

2. Coordinating product delivery

If the insurance company approves coverage:

  • Patient Support Specialists can help coordinate delivery with an in-network specialty pharmacy
  • The specialty pharmacy will reach out to your patient to set up the first shipment

3. Providing ongoing support, such as:

  • Monthly medicine refill reminders. Patients can also choose to receive refill reminders via text message
  • Educational resources about their Vertex medicine
  • Seasonal text and videos, such as open enrollment reminders and tips for sticking to a schedule during summer
  • Tools for staying on track, like resources for starting college, check-in calls, and more

average compliance in patients
enrolled in Vertex GPS nationwide§

§Based on prescription refill data from specialty pharmacies used by Vertex, as well as on-therapy patient records. Data does not include hospital pharmacies and government entities. The compliance calculation uses the PDC (portion of days covered) methodology using 6 months of patient shipment history from 3/1/2022 to 8/31/2022.

Your patient's Patient Support Specialist can send a summary of important information in the Enrolled Patient Report to help assess treatment adherence.

Request a site visit or call your specialist at 1-877-752-5933 (press 2) 1-877-752-5933 (press 2) to review your Enrolled Patient Report.

To contact a Patient Support Specialist, call or text 1-877-752-5933 (press 2 for calls).

Monday–Friday: 8:30 AM to 7 PM ET